Exosomes

Science and Technology

WHAT ARE EXOSOMES?

BENEV Exosome treatments are based on the most cutting edge scientific biotech breakthrough for skin rejuvenation and regeneration. Exosomes are responsible for cell to cell communication and for facilitating the exchange of RNA and other important proteins between cells (e.g. fibroblasts, keratinocytes, immune cells, etc.), in addition to transferring numerous growth factors and cytokines and genetic materials that have shown signs of tissue repair and improving skin cells. These data coding avatars have been harnessed for our new line of exosome products to promote a more radiant youthful appearance.

WHAT IS EXOSCRT™?

Exosome, an 30~200 nm endoplasmic reticulum that is secreted for cell-to-cell communication, plays an important role in influencing the microenvironment around cells, ExoSCRT™ is an innovative technology to separate and refine 0.1% pure exosomes from stem cells and helps the virtualization of natural skin energy by affecting skin cells effectively.

Lyophilizing Exosomes Method

SEE PATENT

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What is exosome

BENEV Exosome Regenerative Complex powered by Exo-SCRT ™ and BENEV Exosome Regenerative Complex + powered by Exo-SCRT™ are post care “topical use” cosmetic solutions. The isolated and purified exosomes in both products have been accepted by the PCPC, and International Cosmetic Ingredient Nomenclature Committee (INC), and the name ‘Human Adipose Stromal Cell Exosomes’ was given and published in the International Cosmetic Ingredient Dictionary and Handbook, known as INCI book. There are at this time no other cosmetic INCI name(s) assigned to exosome products in the market prior to this accomplishment. These products are not drug products. They are not intended to prevent, treat or cure diseases or medical conditions. They are not intended to be injected or delivered intravenously.

IN VIVO TESTING

Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ERC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. ERC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor  (TNF-) in AD skin lesions of Nc/Nga mice. Taken together, these results suggest that ERC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment. (Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon - Stem Cell Research Therapy, BioMedCentral.com)

  • Anti-Inflammatory

     

  • Triple the potency of PRP

  • 180% increase in collagen production

  • 300% increase in elastin production

  • Reduces downtime by 50%

  • Backed by 23 published clinical papers 

  • 8 US patents, 56+ patents globally

  • ExoCoBio is the only pharmaceutical grade manufacturer in the world

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EXO Balm

Post Treatment  &  Home-Care Use

Our clinically proven intensive dual-action post-care optimizing balm is designed to quickly absorb into the skin delivering the concentrated power of exosomes and intensive hydrators to optimize treatment results and reduce downtime.

Recommended For

  • Inflamed skin or skin in need of soothing

  • ​Thin & sensitive skin due to environmental causes or frequent procedure

  • Skin in need of strengthening the skin barrier

  • Skin prone to pigmentation

  • Skin in need of skin texture improvement

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